请教关于ALFF统计分析的问题

Submitted by Carolineqiu on Tue, 02/25/2014 - 01:22

老师，您好，我现在刚接触数据处理，正在做ALFF分析，过程中遇到了一下几个问题，想请教一下：
1.单样本T检验中及双样本T检验中MASK怎么制作啊？我看到http://restfmri.net/forum/node/1040中说“ 制作MASK有个虽然笨但肯定不出错的方法告诉你,save clusters,然后在calculator里自己除以自己,即i1./i1,两幅单样本图都这样处理,相加之后再除以自己”：这个表达式具体怎么写啊？
2.我看到视频中单样本及双样本t检验是对mALFF及 mfALFF进行分析，主要是看这两个结果吗？
3.在Viewer中P值选择0.005、0.01、0.05，这个依据什么选择呢？
4. 在Viewer中做了correcttion threshold by AlphaSim后，与继续做FDR correction冲突吗?
谢谢！

Submitted by YAN Chao-Gan on Tue, 03/04/2014 - 07:02

 1. 表达式写  i1~=0  这个比i1./i1好一点。
2. 或者zALFF或zfALFF。与m的结果差异不大，分布会更正态一些。
3. 校正后0.05就好。
4. 冲突，选一个即好。

超赣

Submitted by Carolineqiu on Fri, 03/07/2014 - 16:18

 谢谢严老师的耐心解答。我现在已经处理好了结果。自己分析了一下，麻烦老师您帮我看一下这样有什么地方不对吗？

Connectivity Criterion: surface connected, edge connected, corner connected.

Number of clusters found: 7

----------------------

Cluster 1

Number of voxels: 25

Peak MNI coordinate: -45 -33 -27

Peak MNI coordinate region:  // Left Cerebrum // Temporal Lobe // Fusiform Gyrus(-45 -33 -27) // Gray Matter // brodmann area 20 // Temporal_Inf_L (aal)

Peak intensity: 4.3797

# voxels  structure

   25     --TOTAL # VOXELS--

   11      Temporal_Inf_L (aal)

    9     Left Cerebrum

    9     Temporal Lobe

    9     Cerebelum_Crus1_L (aal)

    9     Fusiform Gyrus

    5     Culmen

    5     Cerebellum Anterior Lobe

    5     Gray Matter

    5     Left Cerebellum

    4     White Matter

    3     brodmann area 36

    2     brodmann area 20

----------------------

Cluster 2

Number of voxels: 20

Peak MNI coordinate: -30 -36 -15

Peak MNI coordinate region:  // Left Cerebrum // Temporal Lobe // Fusiform Gyrus // Gray Matter // brodmann area 37 // Fusiform_L (aal)

Peak intensity: 4.2723

# voxels  structure

   20     --TOTAL # VOXELS--

   19     Fusiform_L (aal)

   19     Left Cerebrum

   12     Gray Matter

   10     Parahippocampa Gyrus(-30 -36 -15)

   10     Limbic Lobe

    9     Temporal Lobe

    9     Fusiform Gyrus

    6     brodmann area 36

    5     brodmann area 37

    3     White Matter

    1     brodmann area 20

    1     Temporal_Inf_L (aal)

----------------------

Cluster 3

Number of voxels: 21

Peak MNI coordinate: 60   0   3

Peak MNI coordinate region:  // Right Cerebrum // Temporal Lobe // Superior Temporal Gyrus // Gray Matter // brodmann area 22 // Temporal_Sup_R (aal)

Peak intensity: -4.1815

# voxels  structure

   21     --TOTAL # VOXELS--

   21     Right Cerebrum

   17     Temporal Lobe

   15     Superior Temporal Gyrus

   12     Temporal_Sup_R (aal)

   10     Gray Matter

    7     White Matter

    7     brodmann area 22

    7     Rolandic_Oper_R (aal)

    5     Precentral Gyrus(60   0   3)

    4     Frontal Lobe

    2     Temporal_Pole_Sup_R (aal)

    1     brodmann area 42

    1     brodmann area 44

    1     brodmann area 6

    1     Transverse Temporal Gyrus

----------------------

Cluster 4

Number of voxels: 19

Peak MNI coordinate: 24 -96  15

Peak MNI coordinate region:  // Right Cerebrum // Occipital Lobe // Middle Occipital Gyrus(24 -96  15) // Gray Matter // brodmann area 18 // Occipital_Sup_R (aal)

Peak intensity: -3.6299

# voxels  structure

   19     --TOTAL # VOXELS--

   19     Occipital Lobe

   19     Right Cerebrum

   13     Occipital_Sup_R (aal)

   11      Gray Matter

   10     Middle Occipital Gyrus

    9     Cuneus

    7     brodmann area 19

    5     White Matter

    4     brodmann area 18

    3     Occipital_Mid_R (aal)

    1     Cuneus_R (aal)

----------------------

Cluster 5

Number of voxels: 101

Peak MNI coordinate: -54 -63  24

Peak MNI coordinate region:  // Left Cerebrum // Temporal Lobe // Middle Temporal Gyrus // Gray Matter // brodmann area 39 // Angular_L (aal)

Peak intensity: -4.5481

# voxels  structure

  101     --TOTAL # VOXELS--

  101     Left Cerebrum

   79     Temporal Lobe

   54     Gray Matter

   48     Middle Temporal Gyrus

   39     White Matter

   35     brodmann area 39(-54 -63  24)

   34     Temporal_Mid_L (aal)

   31     Superior Temporal Gyrus

   24     Angular_L (aal)

   18     Supramarginal Gyrus

   15     Parietal Lobe

   13     brodmann area 40

   13     SupraMarginal_L (aal)

    7     Occipital Lobe

    5     brodmann area 19

    3     Angular Gyrus

    1     brodmann area 22

    1     Inferior Parietal Lobule

----------------------

Cluster 6

Number of voxels: 51

Peak MNI coordinate: 48 -57  36

Peak MNI coordinate region:  // Right Cerebrum // Parietal Lobe // Angular Gyrus // White Matter // undefined // Angular_R (aal)

Peak intensity: -4.3126

# voxels  structure

   51     --TOTAL # VOXELS--

   50     Right Cerebrum

   48     Parietal Lobe

   45     Angular_R (aal)

   28     White Matter

   22     Angular Gyrus(48 -57  36)

   22     Gray Matter

   14     brodmann area 40

   14     Inferior Parietal Lobule

   12     Supramarginal Gyrus

    8     brodmann area 39

    5     Parietal_Inf_R (aal)

    2     Superior Temporal Gyrus

    2     Temporal Lobe

----------------------

Cluster 7

Number of voxels: 23

Peak MNI coordinate: 3 -66  30

Peak MNI coordinate region:  // Right Cerebrum // Parietal Lobe // Precuneus // undefined // undefined // Precuneus_R (aal)

Peak intensity: -4.3787

# voxels  structure

   23     --TOTAL # VOXELS--

   21     Precuneus(3 -66  30)

   18     Parietal Lobe

   15     Right Cerebrum

   15     Precuneus_R (aal)

   12     Gray Matter

    8     Precuneus_L (aal)

    8     brodmann area 7

    8     Left Cerebrum

    4     brodmann area 31

    3     Occipital Lobe

    2     White Matter
    2     Limbic Lobe 

    1     Cuneus

    1     Cingulate Gyrus



Brain regions

L/R

K

BA

MNI coordinate

T value

x

y

z

MDD＞NC

 

 

 

 

 

 

 

Temporal Lobe

L

25

20

-45

-33

-27

5.36

Fusiform Gyrus

L

20

37

-30

-36

-15

4.27

NC＞MDD

 

 

 

 

 

 

 

Superior Temporal Gyrus

L

21

22

60

0

3

4.18

Occipital Lobe

R

19

18

24

-96

15

3.63

Middle Temporal Gyrus

L

101

39

-54

-63

24

4.55

Angular Gyrus

R

51

39

48

-57

36

4.31

Precuneus

R

23

/

3

-66

30

4.38