关于动态FC及rsfMRI预处理的重采样问题

      各位老师好,投了篇关于rsfMRI的文章,内容是计算FC及其与行为学相关,审稿人问了两个问题,不知该如何回答,希望各位老师提点点子,或者有什么参考文献可循么?万分感谢!问题如下:
      

    问题1:Another significant concern, which may not have a solution in the current test, but which may nevertheless limit generalizability of the results is the dynamic nature of functional networks, which is more accepted nowadays. Given that the FC can change over time, and the neuropsychological test  was not done in concordance with fMRI, the correlation between thalamic FC and neuropsychological test could be by chance.

    问题2:Methods: 2.3.1. Actual voxel size in 3.4 x 3.4 x 6.
Resampling to 3 x 3 x 3 may distort data too much.
Is such a degree of resampling (more than half of original voxel size)
acceptable in rsFMRI analysis?

     

     

1. 你问题题目中提到“动态FC”,下面reviewer的问题中只是提到“thalamic FC”。我猜测你是用的FC,而非动态相关。reviewer提到了一个动态FC的概念,说你的现在的test不能做这个事情,因为在整个时间段内,FC不是‘稳定’或者‘固定’的一个值,它可以在这段时间内变化。ref:  Hutchison, R.M., Womelsdorf, T., Allen, E.A., Bandettini, P.A., Calhoun, V.D., Corbetta, M., Della Penna, S., Duyn, J.H., Glover, G.H., Gonzalez-Castillo, J., Handwerker, D.A., Keilholz, S., Kiviniemi, V., Leopold, D.A., de Pasquale, F., Sporns, O., Walter, M., Chang, C., 2013. Dynamic functional connectivity: promise, issues, and interpretations. Neuroimage 80, 360-378.
2. reviewer说你的原始数据采集厚度是6mm,但是你采样为3x3x3。一下子都distort了2个体素

     非常感谢廖老师的慷慨解疑,是我没表达清楚。
     关于问题1.我用的是基于种子点的FC,但是这个问题,审稿人是在major comment里面提的这个问题的。我有个疑问:rsfMRI本身就是在不思考的情况下完成的扫描,虽然整个扫描时间段的FC是动态变化的,可是这些变化怎么能跟行为学同步呢??除非任务态fMRI才可达到任务跟fMRI的同步了。

    关于问题2:由于我们扫描的层厚是5mm,间距1mm,所以图像体素就大了点,重采样是就根据大家常用的3*3*3了,这种程度的重采样不懂能不能被接受??还是我有必要再修改一下重采样的大小么?貌似我见很多文章都是用3*3*3

     希望能继续得到老师们的指点,谢谢~
    

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