Modulation of functional connectivity during the resting state and the motor task.

 

Hum Brain Mapp. 2004 May;22(1):63-71.

Modulation of functional connectivity during the resting state and the motor task.

Jiang T, He Y, Zang Y, Weng X.

National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China. jiangtz@nlpr.ia.ac.cn

Quite a few studies in functional magnetic resonance imaging (fMRI) have tested that, even in a resting state, motor cortices constitute a network. It has never been investigated how the network modulates from the resting state to the motor task state. In this report, by a newly developed approach taking into account n-to-1 connectivity using 1-to-1 connectivity measures instead of conventional pairwise connectivity, we show the existence of a large organized functional connectivity network related to motor function in the resting brain with fMRI. More importantly, we found that such a network can be modulated from a conscious resting state to planning, initiation, coordination, guidance, and termination of voluntary movement state, exhibited by significant changes of functional connectivity of some brain regions in different brain activity. Moreover, a quantitative description of such a functional modulation has also been presented. Copyright 2004 Wiley-Liss, Inc.