老师：

      您好。我想请教一下您关于SPM8做双因素析因设计方差分析，希望您能在百忙中抽空回复。我想分析一下疾病诊断ZD（正常人，焦虑患者）的脑皮层灰质密度与基因型JY（危险基因位点，正常基因位点）的关系。我之前在网上找了很多资料，都没有办法解决疑问。

      我分析的过程是：首先要分析的图像是经分割并平滑后图像，SPM8中选specify 2^nd-level，参数如下：

想请问一下，rest做vmhc可以采用default mask吗？我看很多文献好像是要自己制作模板。由于不是原始数据，不能制作模板，可以做vmhc吗？

大家好，最近在学习VBM分析，好多文献在报告结果的时候都写的是the cluster-level statistical threshold was set at P < 0.05 corrected with underlying voxel level of p < 0.001 at the non-stationary cluster correction，我只知道FWE,FDR,Alphasim这些校正方法，请问这些文献里这种是什么意思呢

有点糊涂了，是不是用imgcaculater做出来的就是template？

各位老师好：

      我现在在做静息态数据的研究，先用freesurfer对数据进行处理，提取时间序列，导入matlab中，计算相关系数，进行Fisher‘z变换，如何将数据导入图像中变到标准图像中去呢？谢谢！

Dear REST team:

The issue of non-parametric analysis in fMRI study was highlightened again in recent days. I'm wondering is it resonable to use DPARSF for pre-processing combined with other non-parametric toolbox (such as SnPM) for statistical analysis?

Best wishes,

Flora

老师，您好，我用一个AAL脑区作为ROI进行voxel-wise分析，定义好了ROI之后运行会报错，不知道是什么原因呢

Hi there,

 I am using RestPlus to compute functional connectivity when I define my ROI using AAL atlas, it save it as a .nii file but while analysing it looks for .img/.hdr file

I am not sure why it doesnot save as .img/.hdr it gives an error and stops computation when it cannot find the file in right format.

Thanks for your help and suggestions.

Dear REST experts,

Recently a shocking paper has been published which criticize the use of cluster-based parametric correction:

http://www.pnas.org/content/early/2016/06/27/1602413113

This paper also pointed out the bug in 3dClustSim in AFNI, which was left for 15 years until recently. As far as I understand the algorithm in AlphaSim is identical to 3DClustSim. So AlphaSim would have the same bug? Has it been fixed in recent release of REST PLUS?

Thank you in advance,

Jun