Most recent paper

Seed-based test-retest reliability of resting state functional magnetic resonance imaging at 3T and 7T

Mon, 09/06/2021 - 18:00

Med Phys. 2021 Sep 5. doi: 10.1002/mp.15210. Online ahead of print.


PURPOSE: Ultrahigh field (UHF) resting state functional magnetic resonance imaging (rsfMRI) has become increasingly available for clinical and basic research, bringing improvements in resolution and contrast over standard high field imaging. Despite these improvements, UHF connectivity studies present several challenges, including increased sensitivity to physiological confounds and a vastly increased data burden. We present a direct quantitative assessment of test-retest reliability of functional connectivity in several standard functional networks between subjects scanned at 3T and 7T.

METHODS: Five healthy subjects were scanned over 4 sessions each in a scan-rescan design at both 3T and 7T field strengths. Resting state fMRI data were segmented into four major intrinsic connectivity networks, and seed-based peak correlations within and between these networks examined. The reliability of these correlations was assessed using intra-class correlation coefficients (ICC).

RESULTS: Across all data, over 4000 peak correlations were extracted for assessment. The reliability over all intrinsic networks was greater at 7T than 3T (median ICC 0.40 vs 0.33, p ≤ 0.0014), with each network individually showing improvement. Inter-network reliability was stronger than intra-network reliability, but intra-network reliability showed the greatest improvement between field strengths.

CONCLUSION: We demonstrate significantly increased reliability of resting state connectivity at ultrahigh field strengths over conventional field strengths using a novel hybrid seed-based analysis. This result adds to the growing body of work supporting the migration of functional imaging studies to ultrahigh fields. This article is protected by copyright. All rights reserved.

PMID:34486120 | DOI:10.1002/mp.15210

Neuroimaging Anomalies in Community-Dwelling Asymptomatic Adults With Very Early-Stage White Matter Hyperintensity

Mon, 09/06/2021 - 18:00

Front Aging Neurosci. 2021 Aug 16;13:715434. doi: 10.3389/fnagi.2021.715434. eCollection 2021.


White matter hyperintensity (WMH) is common in healthy adults in their 60s and can be seen as early as in their 30s and 40s. Alterations in the brain structural and functional profiles in adults with WMH have been repeatedly studied but with a focus on late-stage WMH. To date, structural and functional MRI profiles during the very early stage of WMH remain largely unexplored. To address this, we investigated multimodal MRI (structural, diffusion, and resting-state functional MRI) profiles of community-dwelling asymptomatic adults with very early-stage WMH relative to age-, sex-, and education-matched non-WMH controls. The comparative results showed significant age-related and age-independent changes in structural MRI-based morphometric measures and resting-state fMRI-based measures in a set of specific gray matter (GM) regions but no global white matter changes. The observed structural and functional anomalies in specific GM regions in community-dwelling asymptomatic adults with very early-stage WMH provide novel data regarding very early-stage WMH and enhance understanding of the pathogenesis of WMH.

PMID:34483884 | PMC:PMC8415566 | DOI:10.3389/fnagi.2021.715434

Cortical Areas Associated With Multisensory Integration Showing Altered Morphology and Functional Connectivity in Relation to Reduced Life Quality in Vestibular Migraine

Mon, 09/06/2021 - 18:00

Front Hum Neurosci. 2021 Aug 16;15:717130. doi: 10.3389/fnhum.2021.717130. eCollection 2021.


Background: Increasing evidence suggests that the temporal and parietal lobes are associated with multisensory integration and vestibular migraine. However, temporal and parietal lobe structural and functional connectivity (FC) changes related to vestibular migraine need to be further investigated. Methods: Twenty-five patients with vestibular migraine (VM) and 27 age- and sex- matched healthy controls participated in this study. Participants completed standardized questionnaires assessing migraine and vertigo-related clinical features. Cerebral cortex characteristics [i.e., thickness (CT), fractal dimension (FD), sulcus depth (SD), and the gyrification index (GI)] were evaluated using an automated Computational Anatomy Toolbox (CAT12). Regions with significant differences were used in a seed-based comparison of resting-state FC conducted with DPABI. The relationship between changes in cortical characteristics or FC and clinical features was also analyzed in the patients with VM. Results: Relative to controls, patients with VM showed significantly thinner CT in the bilateral inferior temporal gyrus, left middle temporal gyrus, and the right superior parietal lobule. A shallower SD was observed in the right superior and inferior parietal lobule. FD and GI did not differ significantly between the two groups. A negative correlation was found between CT in the right inferior temporal gyrus, as well as the left middle temporal gyrus, and the Dizziness Handicap Inventory (DHI) score in VM patients. Furthermore, patients with VM exhibited weaker FC between the left inferior/middle temporal gyrus and the left medial superior frontal gyrus, supplementary motor area. Conclusion: Our data revealed cortical structural and resting-state FC abnormalities associated with multisensory integration, contributing to a lower quality of life. These observations suggest a role for multisensory integration in patients with VM pathophysiology. Future research should focus on using a task-based fMRI to measure multisensory integration.

PMID:34483869 | PMC:PMC8415788 | DOI:10.3389/fnhum.2021.717130

Voxel-Wise Analysis of Structural and Functional MRI for Lateralization of Handedness in College Students

Mon, 09/06/2021 - 18:00

Front Hum Neurosci. 2021 Aug 13;15:687965. doi: 10.3389/fnhum.2021.687965. eCollection 2021.


The brain structural and functional basis of lateralization in handedness is largely unclear. This study aimed to explore this issue by using voxel-mirrored homotopic connectivity (VMHC) measured by resting-state functional MRI (R-fMRI) and gray matter asymmetry index (AI) by high-resolution anatomical images. A total of 50 healthy subjects were included, among them were 13 left-handers, 24 right-handers, and 13 mixed-handers. Structural and R-fMRI data of all subjects were collected. There were significant differences in VMHC among the three groups in lateral temporal-occipital, orbitofrontal, and primary hand motor regions. Meanwhile, there were significant differences in AI that existed in medial prefrontal, superior frontal, and superior temporal regions. Besides, the correlation analysis showed that the closer the handedness score to the extreme of the left-handedness (LH), the stronger the interhemispheric functional connectivity, as well as more leftward gray matter. In general, left/mixed-handedness (MH) showed stronger functional homotopy in the transmodal association regions that depend on the integrity of the corpus callosum, but more variable in primary sensorimotor cortices. Furthermore, the group differences in VMHC largely align with that in AI. We located the specific regions for LH/MH from the perspective of structural specification and functional integration, suggesting the plasticity of hand movement and different patterns of emotional processing.

PMID:34483863 | PMC:PMC8414999 | DOI:10.3389/fnhum.2021.687965

Altered Functional Connectivity in the Resting State Neostriatum After Complete Sleep Deprivation: Impairment of Motor Control and Regulatory Network

Mon, 09/06/2021 - 18:00

Front Neurosci. 2021 Aug 17;15:665687. doi: 10.3389/fnins.2021.665687. eCollection 2021.


Sleep loss not only compromises individual physiological functions but also induces a psychocognitive decline and even impairs the motor control and regulatory network. In this study, we analyzed whole-brain functional connectivity changes in the putamen and caudate nucleus as seed points in the neostriatum after 36 h of complete sleep deprivation in 30 healthy adult men by resting state functional magnetic resonance imaging to investigate the physiological mechanisms involved in impaired motor control and regulatory network in individuals in the sleep-deprived state. The functional connectivity between the putamen and the bilateral precentral, postcentral, superior temporal, and middle temporal gyrus, and the left caudate nucleus and the postcentral and inferior temporal gyrus were significantly reduced after 36 h of total sleep deprivation. This may contribute to impaired motor perception, fine motor control, and speech motor control in individuals. It may also provide some evidence for neurophysiological changes in the brain in the sleep-deprived state and shed new light on the study of the neostriatum in the basal ganglia.

PMID:34483817 | PMC:PMC8416068 | DOI:10.3389/fnins.2021.665687

Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders

Sat, 09/04/2021 - 18:00

Brain Imaging Behav. 2021 Sep 4. doi: 10.1007/s11682-021-00535-3. Online ahead of print.


Young males are often associated with more violence, leading to some serious negative consequences. However, the physiology and the neuroimaging patterns underlying juvenile violence remain unclear. Of the limited knowledge on juvenile violence, the default mode network has been known to be associated with its pathophysiology. This study aimed to investigate functional connectivity alterations of the default mode network in male juvenile violent offenders. 31 juvenile violent offenders in a high-security facility, who were convicted of aggressive behaviors by court, and 28 normal controls from a middle school were recruited as participants. They underwent a resting-state functional magnetic resonance imaging scan. And independent component analysis approaches were used to analyze their data. Compared to the normal controls, the juvenile violent offenders showed a different default mode network pattern, with the functional connectivity increased in the posterior cingulate, and decreased in the right middle temporal, left angular, right precuneus and right middle frontal cortex. Our findings revealed that the male juvenile violent offenders were associated with abnormal default mode network functional connectivity, which might be a neuroimaging basis for their tendency to violence.

PMID:34480692 | DOI:10.1007/s11682-021-00535-3

Advances in resting state fMRI acquisitions for functional connectomics

Fri, 09/03/2021 - 18:00

Neuroimage. 2021 Aug 31;243:118503. doi: 10.1016/j.neuroimage.2021.118503. Online ahead of print.


Resting state functional magnetic resonance imaging (rs-fMRI) is based on spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal, which occur simultaneously in different brain regions, without the subject performing an explicit task. The low-frequency oscillations of the rs-fMRI signal demonstrate an intrinsic spatiotemporal organization in the brain (brain networks) that may relate to the underlying neural activity. In this review article, we briefly describe the current acquisition techniques for rs-fMRI data, from the most common approaches for resting state acquisition strategies, to more recent investigations with dedicated hardware and ultra-high fields. Specific sequences that allow very fast acquisitions, or multiple echoes, are discussed next. We then consider how acquisition methods weighted towards specific parts of the BOLD signal, like the Cerebral Blood Flow (CBF) or Volume (CBV), can provide more spatially specific network information. These approaches are being developed alongside the commonly used BOLD-weighted acquisitions. Finally, specific applications of rs-fMRI to challenging regions such as the laminae in the neocortex, and the networks within the large areas of subcortical white matter regions are discussed. We finish the review with recommendations for acquisition strategies for a range of typical applications of resting state fMRI.

PMID:34479041 | DOI:10.1016/j.neuroimage.2021.118503

Increased resting-state brain entropy of parahippocampal gyrus and dorsolateral prefrontal cortex in manic and euthymic adolescent bipolar disorder

Fri, 09/03/2021 - 18:00

J Psychiatr Res. 2021 Aug 26;143:106-112. doi: 10.1016/j.jpsychires.2021.08.025. Online ahead of print.


BACKGROUND: Alterations of brain signal complexity may reflect brain functional abnormalities. In adolescent bipolar disorder (ABD) distribution of brain regions showing abnormal complexity in different mood states remains unclear. We aimed to analyze brain entropy (BEN) alteration of functional magnetic resonance imaging (fMRI) signal to observe spatial distribution of complexity in ABD patients, as well as the relationship between this variation and clinical variables.

METHODS: Resting-state fMRI data were acquired from adolescents with bipolar disorder (BD) who were in manic (n = 19) and euthymic (n = 20) states, and from healthy controls (HCs, n = 17). The differences in BEN among the three groups, and their associations with clinical variables, were examined.

RESULTS: Compared to HCs, manic and euthymic ABD patients showed increased BEN in right parahippocampal gyrus (PHG) and left dorsolateral prefrontal cortex (DLPFC). There was no significant difference of BEN between the manic and the euthymic ABD groups. In manic ABD patients, right PHG BEN exhibited significantly positive relationship with episode times.

CONCLUSIONS: Increased BEN in right PHG and left DLPFC in ABD patients may cause dysfunction of corticolimbic circuitry which is important to emotional processing and cognitive control. The positive correlation between PHG BEN and episode times of manic ABD patients further expressed a close association between brain complexity and clinical symptoms. From the perspective of brain temporal dynamics, the present study complements previous findings that have reported corticolimbic dysfunction as an important contributor to the pathophysiology of BD. BEN may provide valuable evidences for understanding the underlying mechanism of ABD.

PMID:34479001 | DOI:10.1016/j.jpsychires.2021.08.025

An isotropic EPI database and analytical pipelines for rat brain resting-state fMRI

Fri, 09/03/2021 - 18:00

Neuroimage. 2021 Aug 31:118541. doi: 10.1016/j.neuroimage.2021.118541. Online ahead of print.


Resting-state functional magnetic resonance imaging (fMRI) has drastically expanded the scope of brain research by advancing our knowledge about the topologies, dynamics, and interspecies translatability of functional brain networks. Several databases have been developed and shared in accordance with recent key initiatives in the rodent fMRI community to enhance the transparency, reproducibility, and interpretability of data acquired at various sites. Despite these pioneering efforts, one notable challenge preventing efficient standardization in the field is the customary choice of anisotropic echo planar imaging (EPI) schemes with limited spatial coverage. Imaging with anisotropic resolution and/or reduced brain coverage has significant shortcomings including reduced registration accuracy and increased deviation in brain feature detection. Here we proposed a high-spatial-resolution (0.4 mm), isotropic, whole-brain EPI protocol for the rat brain using a horizontal slicing scheme that can maintain a functionally relevant repetition time (TR), avoid high gradient duty cycles, and offer unequivocal whole-brain coverage. Using this protocol, we acquired resting-state EPI fMRI data from 87 healthy rats under the widely used dexmedetomidine sedation supplemented with low-dose isoflurane on a 9.4 T MRI system. We developed an EPI template that closely approximates the Paxinos and Watson's rat brain coordinate system and demonstrated its ability to improve the accuracy of group-level approaches and streamline fMRI data pre-processing. Using this database, we employed a multi-scale dictionary-learning approach to identify reliable spatiotemporal features representing rat brain intrinsic activity. Subsequently, we performed k-means clustering on those features to obtain spatially discrete, functional regions of interest (ROIs). Using Euclidean-based hierarchical clustering and modularity-based partitioning, we identified the topological organizations of the rat brain. Additionally, the identified group-level FC network appeared robust across strains and sexes. The "triple-network" commonly adapted in human fMRI were resembled in the rat brain. Through this work, we disseminate raw and pre-processed isotropic EPI data, a rat brain EPI template, as well as identified functional ROIs and networks in standardized rat brain coordinates. We also make our analytical pipelines and scripts publicly available, with the hope of facilitating rat brain resting-state fMRI study standardization.

PMID:34478824 | DOI:10.1016/j.neuroimage.2021.118541

Disrupted functional connectivity in white matter resting-state networks in unilateral temporal lobe epilepsy

Fri, 09/03/2021 - 18:00

Brain Imaging Behav. 2021 Sep 3. doi: 10.1007/s11682-021-00506-8. Online ahead of print.


Unilateral temporal lobe epilepsy (TLE) is the most common type of focal epilepsy characterized by foci in the unilateral temporal lobe grey matters of regions such as the hippocampus. However, it remains unclear how the functional features of white matter are altered in TLE. In the current study, resting-state functional magnetic resonance imaging (fMRI) was performed on 71 left TLE (LTLE) patients, 79 right TLE (RTLE) patients and 47 healthy controls (HC). Clustering analysis was used to identify fourteen white matter networks (WMN). The functional connectivity (FC) was calculated among WMNs and between WMNs and grey matter. Furthermore, the FC laterality of hemispheric WMNs was assessed. First, both patient groups showed decreased FCs among WMNs. Specifically, cerebellar white matter illustrated decreased FCs with the cerebral superficial WMNs, implying a dysfunctional interaction between the cerebellum and the cerebral cortex in TLE. Second, the FCs between WMNs and the ipsilateral hippocampus (grey matter foci) were also reduced in patient groups, which may suggest insufficient functional integration in unilateral TLE. Interestingly, RTLE showed more severe abnormalities of white matter FCs, including links to the bilateral hippocampi and temporal white matter, than LTLE. Taken together, these findings provide functional evidence of white matter abnormalities, extending the understanding of the pathological mechanism of white matter impairments in unilateral TLE.

PMID:34478055 | DOI:10.1007/s11682-021-00506-8

Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder

Fri, 09/03/2021 - 18:00

Psychopharmacology (Berl). 2021 Sep 3. doi: 10.1007/s00213-021-05915-7. Online ahead of print.


RATIONAL: With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for facilitating work on response biomarkers.

OBJECTIVES: To identify differences in patterns of pre-treatment resting-state functional connectivity (rsFC) that may underlie response to antidepressant treatment.

METHODS: After a baseline MRI scan, thirty-four drug-free patients with depression were treated with an SSRI escitalopram 10 mg daily for 6 weeks; response was defined as ≥ 50% decrease in Hamilton Depression Rating Scale (HAMD) score. Thirty-one healthy controls had a baseline clinical assessment and scan. Healthy participants did not receive treatment.

RESULTS: Twenty-one (62%) of patients responded to escitalopram. Treatment responsivity was associated with enhanced rsFC of the right fronto-parietal network (FPN)-with the posterior DMN, somatomotor network (SMN) and somatosensory association cortex. The lack of treatment response was characterized by reduced rsFC: of the bilateral FPN with the contralateral SMN, of the right FPN with the posterior DMN, and of the extended sensorimotor auditory area with the inferior parietal lobule (IPL) and posterior DMN. Reduced rsFC of the posterior DMN with IPL was seen in treatment responders, although only when compared with HC.

CONCLUSIONS: The study supports the role of resting-state networks in response to antidepressant treatment, and in particular the central role of the frontoparietal and default mode networks.

PMID:34477887 | DOI:10.1007/s00213-021-05915-7

Time-delay structure predicts clinical scores for patients with disorders of consciousness using resting-state fMRI

Thu, 09/02/2021 - 18:00

Neuroimage Clin. 2021 Aug 28;32:102797. doi: 10.1016/j.nicl.2021.102797. Online ahead of print.


BACKGROUND: The detection of intrinsic brain activity (iBA) could assist clinical assessment for disorder of consciousness (DOC) patients. Previous studies have revealed the altered iBA in thalamocortical, frontoparietal, and default mode network in DOC patients using functional connectivity (FC) analysis. However, due to the assumption of synchronized iBA in FC, these studied may be inadequate for understanding the effect of severe brain injury on the temporal organization of iBA and the relationship between temporal organization and clinical feature in DOC patients. Recently, the time delay estimation (TDE) and probabilistic flow estimation (PFE) were proposed to analyze temporal organization, which could provide propagation structure and propagation probability at whole-brain level.

METHODS: We applied voxel-wise TDE and PFE to assess propagation structure and propagation probability for the DOC patients and then applied the connectome-based predictive modeling (CPM) to predict clinical scores for patients based on the ROI-wise TDE and PFE.

RESULTS: We found that: 1) the DOC patients showed abnormal voxel-wise time delay (TD) and probabilistic flow (PF) in the precentral gyrus, precuneus, middle cingulate cortex, and postcentral gyrus, 2) the range of TD value in the patients was shorter than that in the controls, and 3) the ROI-wise TD had a better predictive performance for clinical scores of the patients compared with that based on ROI-wise PF.

CONCLUSION: Our findings may suggest that the propagation structure of iBA could be used to predict clinical scores in DOC patients.

PMID:34474318 | DOI:10.1016/j.nicl.2021.102797

Automated eloquent cortex localization in brain tumor patients using multi-task graph neural networks

Thu, 09/02/2021 - 18:00

Med Image Anal. 2021 Aug 21;74:102203. doi: 10.1016/ Online ahead of print.


Localizing the eloquent cortex is a crucial part of presurgical planning. While invasive mapping is the gold standard, there is increasing interest in using noninvasive fMRI to shorten and improve the process. However, many surgical patients cannot adequately perform task-based fMRI protocols. Resting-state fMRI has emerged as an alternative modality, but automated eloquent cortex localization remains an open challenge. In this paper, we develop a novel deep learning architecture to simultaneously identify language and primary motor cortex from rs-fMRI connectivity. Our approach uses the representational power of convolutional neural networks alongside the generalization power of multi-task learning to find a shared representation between the eloquent subnetworks. We validate our method on data from the publicly available Human Connectome Project and on a brain tumor dataset acquired at the Johns Hopkins Hospital. We compare our method against feature-based machine learning approaches and a fully-connected deep learning model that does not account for the shared network organization of the data. Our model achieves significantly better performance than competing baselines. We also assess the generalizability and robustness of our method. Our results clearly demonstrate the advantages of our graph convolution architecture combined with multi-task learning and highlight the promise of using rs-fMRI as a presurgical mapping tool.

PMID:34474216 | DOI:10.1016/

Age differences in intuitive moral decision-making: Associations with inter-network neural connectivity

Thu, 09/02/2021 - 18:00

Psychol Aging. 2021 Sep 2. doi: 10.1037/pag0000633. Online ahead of print.


Positions of power involving moral decision-making are often held by older adults (OAs). However, little is known about age differences in moral decision-making and the intrinsic organization of the aging brain. In this study, younger adults (YAs; n = 117, Mage = 22.11) and OAs (n = 82, Mage = 67.54) made decisions in hypothetical moral dilemmas and completed resting-state multi-echo functional magnetic resonance imaging (fMRI) scans. Relative to YAs, OAs were more likely to endorse deontological decisions (i.e., decisions based on adherence to a moral principle or duty), but only when the choice was immediately compelling or intuitive. By contrast, there was no difference between YAs and OAs in utilitarian decisions (i.e., decisions aimed at maximizing collective well-being) when the utilitarian choice was intuitive. Enhanced connections between the posterior medial core of the default network (pmDN) and the dorsal attention network, and overall reduced segregation of pmDN from the rest of the brain, were associated with this increased deontological-intuitive moral decision-making style in OAs. The present study contributes to our understanding of age differences in decision-making styles by taking into account the intuitiveness of the moral choice, and it offers further insights as to how age differences in intrinsic brain connectivity relate to these distinct moral decision-making styles in YAs and OAs. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

PMID:34472915 | DOI:10.1037/pag0000633

Between-sex variability of resting state functional brain networks in amyotrophic lateral sclerosis (ALS)

Thu, 09/02/2021 - 18:00

J Neural Transm (Vienna). 2021 Sep 1. doi: 10.1007/s00702-021-02413-0. Online ahead of print.


The organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in site of onset, phenotypes, and prognosis. Here, we explored resting state (RS) FC differences within major large-scale functional networks between women and men in a sample of ALS patients, in comparison to healthy controls (HCs). A group-level independent component analysis (ICA) was performed on RS-fMRI time-series enabling spatial and spectral analyses of large-scale RS FC networks in 45 patients with ALS (20 F; 25 M) and 31 HCs (15 F; 16 M) with a focus on sex-related differences. A whole-brain voxel-based morphometry (VBM) was also performed to highlight atrophy differences. Between-sex comparisons showed: decreased FC in the right middle frontal gyrus and in the precuneus within the default mode network (DMN), in affected men compared to affected women; decreased FC in the right post-central gyrus (sensorimotor network), in the right inferior parietal gyrus (right fronto-parietal network) and increased FC in the anterior cingulate cortex and right insula (salience network), in both affected and non-affected men compared to women. When comparing affected men to affected women, VBM analysis revealed atrophy in men in the right lateral occipital cortex. Our results suggest that in ALS sex-related trends of brain functional and structural changes are more heavily represented in DMN and in the occipital cortex, suggesting that sex is an additional dimension of functional and structural heterogeneity in ALS.

PMID:34471976 | DOI:10.1007/s00702-021-02413-0

Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults

Thu, 09/02/2021 - 18:00

Neurobiol Stress. 2021 Aug 21;15:100385. doi: 10.1016/j.ynstr.2021.100385. eCollection 2021 Nov.


Nearly 14 percent of Americans live in a socioeconomically disadvantaged neighborhood. Lower individual socioeconomic position (iSEP) has been linked to increased exposure to trauma and stress, as well as to alterations in brain structure and function; however, the neural effects of neighborhood SEP (nSEP) factors, such as neighborhood disadvantage, are unclear. Using a multi-modal approach with participants who recently experienced a traumatic injury (N = 185), we investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and iSEP on brain structure and functional connectivity at rest. After controlling for iSEP, demographic variables, and acute PTSD symptoms, nSEP was associated with decreased volume and alterations of resting-state functional connectivity in structures implicated in affective processing, including the insula, ventromedial prefrontal cortex, amygdala, and hippocampus. Even in individuals who have recently experienced a traumatic injury, and after accounting for iSEP, the impact of living in a disadvantaged neighborhood is apparent, particularly in brain regions critical for experiencing and regulating emotion. These results should inform future research investigating how various levels of socioeconomic circumstances may impact recovery after a traumatic injury as well as policies and community-developed interventions aimed at reducing the impact of socioeconomic stressors.

PMID:34471656 | PMC:PMC8390770 | DOI:10.1016/j.ynstr.2021.100385

Interpreting null models of resting-state functional MRI dynamics:not throwing the model out with the hypothesis

Wed, 09/01/2021 - 18:00

Neuroimage. 2021 Aug 29;243:118518. doi: 10.1016/j.neuroimage.2021.118518. Online ahead of print.


Null models are useful for assessing whether a dataset exhibits a non-trivial property of interest. These models have recently gained interest in the neuroimaging community as means to explore dynamic properties of functional Magnetic Resonance Imaging (fMRI) time series. Interpretation of null-model testing in this context may not be straightforward because (i) null hypotheses associated to different null models are sometimes unclear and (ii) fMRI metrics might be 'trivial', i.e. preserved under the null hypothesis, and still be useful in neuroimaging applications. In this commentary, we review several commonly used null models of fMRI time series and discuss the interpretation of the corresponding tests. We argue that, while null-model testing allows for a better characterization of the statistical properties of fMRI time series and associated metrics, it should not be considered as a mandatory validation step to assess their relevance in representing brain functional dynamics.

PMID:34469853 | DOI:10.1016/j.neuroimage.2021.118518

Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders

Wed, 09/01/2021 - 18:00

Neuroimage Clin. 2021 Aug 21;32:102789. doi: 10.1016/j.nicl.2021.102789. Online ahead of print.


BACKGROUND: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-deficit/hyperactivity disorder (ADHD).

METHODS: The current study used functional magnetic resonance imaging(fMRI) to examine sex differences in resting-state seed-based FC, self-rated impulsivity, and their interactions in 11-12-year-old boys (n = 43) and girls (n = 43) with externalizing disorders. Generalized linear models controlling for pubertal development were used. Seeds were chosen in the ventral striatum, medial prefrontal cortex, middle frontal gyrus and amygdala.

RESULTS: Impulsivity scores were greater in boys than girls (p < 0.05). Boys showed greater positive connectivity within a ventromedial prefrontal-ventral striatal network. In addition, boys demonstrated weaker connectivity than girls within two medial-lateral prefrontal cortical networks. However, only boys showed greater medial-lateral prefrontal connectivity correlated with greater impulsivity.

CONCLUSIONS: The findings provide evidence supporting sex differences in both ventral striatal-ventromedial prefrontal and medial-lateral prefrontal functional networks in youth with externalizing disorders. These important networks are thought to be implicated in impulse control. Medial-lateral prefrontal connectivity may represent a male-specific biomarker of impulsivity.

PMID:34469847 | DOI:10.1016/j.nicl.2021.102789

Resting-state functional connectivity and reading subskills in children

Wed, 09/01/2021 - 18:00

Neuroimage. 2021 Aug 29:118529. doi: 10.1016/j.neuroimage.2021.118529. Online ahead of print.


Individual differences in reading ability have been linked to characteristics of functional connectivity in the brain in both children and adults. However, many previous studies have used single or composite measures of reading, leading to difficulty characterizing the role of functional connectivity in discrete subskills of reading. The present study addresses this issue using resting-state fMRI to examine how resting-state functional connectivity (RSFC) related to individual differences in children's reading subskills, including decoding, sight word reading, reading comprehension, and rapid automatized naming (RAN). Findings showed both positive and negative RSFC-behaviour relationships that diverged across different reading subskills. Positive relationships included increasing RSFC among left dorsal and anterior regions with increasing decoding proficiency, and increasing RSFC between the left thalamus and right fusiform gyrus with increasing sight word reading, RAN, and reading comprehension abilities. In contrast, negative relationships suggested greater functional segregation of attentional and reading networks with improved performance on RAN, decoding, and reading comprehension tasks. Importantly, the results suggest that although reading subskills rely to some extent on shared functional networks, there are also distinct functional connections supporting different components of reading ability in children.

PMID:34469812 | DOI:10.1016/j.neuroimage.2021.118529

Increased network centrality of the anterior insula in early abstinence from alcohol

Wed, 09/01/2021 - 18:00

Addict Biol. 2021 Aug 31:e13096. doi: 10.1111/adb.13096. Online ahead of print.


Abnormal resting-state functional connectivity, as measured by functional magnetic resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings are so far inconsistent. Here, we exploited recent developments in graph-theoretical analyses, enabling improved resolution and fine-grained representation of brain networks, to investigate functional connectivity in 35 recently detoxified alcohol dependent patients versus 34 healthy controls. Specifically, we focused on the modular organization, that is, the presence of tightly connected substructures within a network, and on the identification of brain regions responsible for network integration using an unbiased approach based on a large-scale network composed of more than 600 a priori defined nodes. We found significant reductions in global connectivity and region-specific disruption in the network topology in patients compared with controls. Specifically, the basal brain and the insular-supramarginal cortices, which form tightly coupled modules in healthy subjects, were fragmented in patients. Further, patients showed a strong increase in the centrality of the anterior insula, which exhibited stronger connectivity to distal cortical regions and weaker connectivity to the posterior insula. Anterior insula centrality, a measure of the integrative role of a region, was significantly associated with increased risk of relapse. Exploratory analysis suggests partial recovery of modular structure and insular connectivity in patients after 2 weeks. These findings support the hypothesis that, at least during the early stages of abstinence, the anterior insula may drive exaggerated integration of interoceptive states in AUD patients with possible consequences for decision making and emotional states and that functional connectivity is dynamically changing during treatment.

PMID:34467604 | DOI:10.1111/adb.13096